The healthcare system in the United States is facing a crisis of high costs and low quality. The culprit? Big Medicine, a term that encompasses the powerful conglomerates controlling the industry. These include pharmaceutical giants, insurance companies, and pharmacy benefit managers (PBMs), who act as intermediaries between insurers, drug manufacturers, and pharmacies. The issue is not just about drug prices; it's about the entire ecosystem of healthcare costs and the lack of competition. The "big three" PBMs, in particular, control a staggering 80% of U.S. prescriptions and are vertically integrated with major insurance and pharmacy chains. This integration allows them to manipulate drug costs and drive independent pharmacies out of business. The situation is so dire that it has sparked a movement to break up these monopolistic entities. The Break Up Big Medicine Act, introduced by Senators Warren and Hawley, aims to prevent insurers, PBMs, and wholesalers from owning or controlling healthcare providers, including medical practices and pharmacies. This legislation is supported by a growing coalition of patients, clinicians, employers, and policy experts, who argue that these conglomerates have too much control over medical decisions and drive up costs without investing in patient care. The comparison to the Glass-Steagall Act during the Great Depression is apt. Just as the separation of commercial and investment banks was necessary to prevent systemic risks, breaking up Big Medicine could be a crucial step towards a more competitive and patient-centric healthcare system. The challenge is clear: the current system is failing patients and the economy alike. It's time for bold action to restore balance and transparency in healthcare.